In terms of use, tissue paper cannot be used more than once. On the other hand, a handkerchief was used hundreds of times.
Paper towels are purchased in bulk and are not very expensive. On the other hand, depending on the material, the price of a handkerchief can be cheap or very expensive.
Paper towels were invented in 1890 and later a company brought some changes in 1935, while handkerchiefs are thought to have originated in the 14th century.
The production of paper towels is based entirely on pulp or wood paper. Handkerchiefs, on the other hand, are made of different types of fabrics.
Paper towels are not washed after they are used up as they can be easily damaged and recycled or thrown away, whereas one can wash their hands as much as they want.